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M94A2651.TXT
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Document 2651
DOCN M94A2651
TI Clinical markers in the diagnosis of perinatal HIV infection.
DT 9412
AU Arabe J; Rubini NP; Guimaraes MD; Crasto MC; Sion FS; Morais-de-Se CA;
Gaffree & Guinle University Hospital, University of Rio de; Janeiro,
Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):256 (abstract no. PB0452). Unique
Identifier : AIDSLINE ICA10/94369924
AB OBJECTIVE: To identificate clinical markers usefull in the diagnosis of
vertically acquired HIV infection. METHODS: We retrospectively analysed
89 infants born to HIV-infected mothers between Aug 86 and Jun 92. All
the infants were HIV-antibody positive at birth and had clinical
follow-up from birth to 18 months of age. HIV infection diagnostic was
according to CDC criteria. The clinical variables analysed were:
persistent generalized lymphadenopathy (PGL), hepatomegaly/splenomegaly
(HS), diarrhea persistent or recurrent (DP/R), parotiditis (PR),
dermatitis (DR), bacterial pneumonia (BP), severe bacterial infection
(SBI), Tuberculosis (TB), thrush (TH), and failure-to-thrive (FTT). The
statistic analysis includes the evaluation of the sensitivity,
specificity, positive and negative preditive values (PPV and NPV).
RESULTS: Among the analysed infants 38 (42.7%) were infected by HIV and
51 (57.3%) were uninfected. Analysis of sensitivity, specificity, PPV
and NPV of the clinical findings are demonstrated in the table bellow:
TABULAR DATA, SEE ABSTRACT VOLUME. CONCLUSIONS: 1) Clinical variables
analysed didn't demonstrate diagnostic value in a isolated way. 2) The
presence of two clinical findings concomitantly gives a significative
increase the diagnostic acuracity.
DE AIDS-Related Opportunistic Infections/*DIAGNOSIS/TRANSMISSION Brazil
*Developing Countries Female Follow-Up Studies Human HIV
Infections/*DIAGNOSIS/TRANSMISSION HIV
Seropositivity/*DIAGNOSIS/TRANSMISSION Infant Infant, Newborn Male
Pregnancy MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).